(371) PREEMPT: Prospective from complex patients in practice
نویسندگان
چکیده
منابع مشابه
The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients.
CONTEXT Pyruvate dehydrogenase complex (PDC) deficiency is a genetic mitochondrial disorder commonly associated with lactic acidosis, progressive neurological and neuromuscular degeneration and, usually, death during childhood. There has been no recent comprehensive analysis of the natural history and clinical course of this disease. OBJECTIVE We reviewed 371 cases of PDC deficiency, publishe...
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The retina contains due families of phspbolipnsc C (P, 6. and u). a reccctor-activated ewYmC that PFeratcs two iolraceUuhv s%xmd n&cngcrs, diacylgly&ol md I ,$5-inositol rrispbospbale. We hnvc charactaizcd the cDNA and par&d gene sh-ucnue for human PLCB4, a p isofurm which shares uighcsr sequence homology with dx norpA PLC from Drosophila. A muwion in tie nor@ PU: leads m I retinal demmtioo m d...
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The carbonate sedimentary record contains diverse compositions and textures that reflect the evolution of oceans and atmospheres through geological time. Efforts to reconstruct paleoenvironmental conditions from these deposits continue to be hindered by the need for process-based models that can explain observed shifts in carbonate chemistry and form. Traditional interpretations assume minerals...
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The plasma concentration of repaglinide is reported to increase greatly when given after repeated oral administration of itraconazole and gemfibrozil. The present study analyzed this interaction based on a physiologically based pharmacokinetic (PBPK) model incorporating inhibition of the hepatic uptake transporter and metabolic enzymes involved in repaglinide disposition. Firstly, the plasma co...
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ژورنال
عنوان ژورنال: The Journal of Pain
سال: 2017
ISSN: 1526-5900
DOI: 10.1016/j.jpain.2017.02.345